Heat-shock protein 90 (Hsp90)

Authors

Affiliations

Nate Yomogida, B.S., SPT

Doctor of Physical Therapy

B.S. in Kinesiology

Chloë Kerstein, B.S., SPT

Doctor of Physical Therapy

B.A. in Neuroscience

Direct Effects

Indirect effects

Abnormal Expression

Abnormal expression of Hsp90 has been attributed to pulmonary arterial hypertension (PAH)¹.

Interplay

Hsp90 may have a strong interaction with PPAR-γ¹. Hsp90 can play a role to stabilize PPAR-γ in liver cells and adipocytes¹. Thus when Hsp90 expression is increased, the PPAR-γ experiences improvements in stability and levels. Hsp90 overexpression diminishes PPAR-γ degredation¹. The opposite effect is also true, when Hsp90 is inhibited, PPAR-γ levels are decreased¹.

References

1.

Kökény G, Calvier L, Hansmann G. PPAR\(\gamma\) and TGF\(\beta\)-Major Regulators of Metabolism, Inflammation, and Fibrosis in the Lungs and Kidneys. International Journal of Molecular Sciences. 2021;22(19):10431. doi:10.3390/ijms221910431