Neuroinflammation
Function of inflammation
Relation to Pathology
Alzheimer’s Disease
- Weaver Donald proposed that neuroinflammation was the common denominator in unifying 30 different risk factors of Alzheimer’s Disease1.
- Some claim that dysfunction of neuroimmune-neuroinflammation axis was resulting in 30 identified risk factors1.
- More specifically, the activation of glial cells and the release of pro-inflammatory proteins common physiological pathways of these risk factors1.
Amyotrophic lateral sclerosis
- In a rewiew by Yang et al, the authors focused on the role of astrocytes specifically non-cell-autonomous role of astrocytes1.
- Yang concluded that strocytes play a key role in ALS development through disruption of Ca2+ homeostasis, mitochondrial function, lipid metabolismn, lactate metabolism, glutamate excitotoxicity, and other pathways1.
Read more about ALS here
Chronic Idiopathic Demyelinating Polyneuropathy (CIDP)
CIDP is an acquired immunomediate neuropathy1.
Treatment of CIDP includes subcutaneous immunoglobulin (SCIgs)1. A recent study found that SCIgs could preserve nerve function in CIDP1.
Read more about CIDP here
Purinergic Signalling
Lifestyle factors
Management
Management of neuroinflammation can be broken down into a variety of factors:
- sleep optimization
- Diet
- Avoiding environmental toxins
- Mold?
- Stress
- Socializing
- Exercise
Treatment
Sleep
“Sleep deprivation could adversely impact immune function, cognitive memory, learning ability, etc. Studies have revealed that sleep deprivation can lead to inflammatory responses in the CNS. Li et al. investigated the protective role of dexmedetomidine, an anesthetic compound, in sleep deprivation by focusing on its possible anti-inflammatory role in the CNS. In a sleep deprivation mouse model, the authors claimed that dexmedetomidine could significantly improve anxiety-like behaviors in the sleep-deprived mice and could attenuate inflammatory responses and oxidative stress in the CNS by inhibiting the activation of the p38/MSK1/NFκB pathway (Contribution 7).”1.
Diet optimization
Diet has a large impact on health