α-synucleinopathies

Authors

Affiliations

Nate Yomogida, B.S., SPT

Doctor of Physical Therapy

B.S. in Kinesiology

Chloë Kerstein, B.S., SPT

Doctor of Physical Therapy

B.A. in Neuroscience

“Importantly, GI symptoms (hypersalivation, dyspepsia, constipation, abdominal pain, or defecatory dysfunction) are common non-motor manifestations of PD with at least one of them present in 60–80% of PD patients [1,2]. In support of Braak’s hypothesis, several research groups propose that these non-motor symptoms may indicate the onset of α-syn pathology”¹

References

1.

Montalbán-Rodríguez A, Abalo R, López-Gómez L. From the Gut to the Brain: The Role of Enteric Glial Cells and Their Involvement in the Pathogenesis of Parkinson’s Disease. International Journal of Molecular Sciences. 2024;25(2):1294. doi:10.3390/ijms25021294