Gut-Brain Axis Theory of PD
Braak’s Hypothesis
Movement of α-syn to the CNS
Furthermore, it was observed that vagal nerve sections prevented the intestine-to-brain propagation of fibrils and neurodegeneration [11]. Thus, the vagus nerve seems to serve as the conduit for α-syn propagation from the gut to the CNS1
References
1.
Montalbán-Rodríguez A, Abalo R, López-Gómez L. From the Gut to the Brain: The Role of Enteric Glial Cells and Their Involvement in the Pathogenesis of Parkinson’s Disease. International Journal of Molecular Sciences. 2024;25(2):1294. doi:10.3390/ijms25021294
Citation
For attribution, please cite this work as:
Yomogida N, Kerstein C. Gut-Brain Axis Theory
of PD. https://yomokerst.com/The
Archive/Neuroscience/Neuropathology/Parkinsons
Disease/gut_brain_PD_theory.html