Gut-Brain Axis Theory of PD

Authors
Affiliations

Doctor of Physical Therapy

B.S. in Kinesiology

Doctor of Physical Therapy

B.A. in Neuroscience

Braak’s Hypothesis

  1. α-syn is produced in the periphery1
  2. α-syn proagates to the CNS1
  3. α-syn in the CNS causes the disease1

Movement of α-syn to the CNS

Furthermore, it was observed that vagal nerve sections prevented the intestine-to-brain propagation of fibrils and neurodegeneration [11]. Thus, the vagus nerve seems to serve as the conduit for α-syn propagation from the gut to the CNS1

References

1.
Montalbán-Rodríguez A, Abalo R, López-Gómez L. From the Gut to the Brain: The Role of Enteric Glial Cells and Their Involvement in the Pathogenesis of Parkinson’s Disease. International Journal of Molecular Sciences. 2024;25(2):1294. doi:10.3390/ijms25021294

Citation

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