Synaptic Cleft

Authors

Affiliations

Nate Yomogida, B.S., SPT

Doctor of Physical Therapy

B.S. in Kinesiology

Chloë Kerstein, B.S., SPT

Doctor of Physical Therapy

B.A. in Neuroscience

AKA

• Synaptic Space¹
• Synaptic Cleft¹

Electron micrographic appearance of the contact point between a single axon terminal and the muscle fiber membrane¹

The synaptic cleft refers to the space between the terminal and the fiber membrane¹. The synaptic cleft is 20 to 30 nanometers wide¹.

Role in Excitation

ACh being released into the synapti cleft after nerve depolarization¹

When the nerve is excited, ACh is released into the synaptic cleft¹.

References

1.

Hall JE, Hall ME, Guyton AC. Guyton and Hall Textbook of Medical Physiology. 14th edition. Elsevier; 2021.