Transforming Growth Factor Beta (TGF-β)

Authors

Affiliations

Nate Yomogida, B.S., SPT

Doctor of Physical Therapy

B.S. in Kinesiology

Chloë Kerstein, B.S., SPT

Doctor of Physical Therapy

B.A. in Neuroscience

TGF-β is a multifunctional cytokine that drives inflammation, fibrosis, and cell differentiation¹

Relationship to PPAR-γ

While TGF-β facilitates inflammation, fibrosis, and cell differentiation, PPAR-γ functions to reverse these adverse events¹

References

1.

Kökény G, Calvier L, Hansmann G. PPAR\(\gamma\) and TGF\(\beta\)-Major Regulators of Metabolism, Inflammation, and Fibrosis in the Lungs and Kidneys. International Journal of Molecular Sciences. 2021;22(19):10431. doi:10.3390/ijms221910431