Peroxisome Proliferator-Activated Receptor Subfamily (PPAR)

Authors

Affiliations

Nate Yomogida, B.S., SPT

Doctor of Physical Therapy

B.S. in Kinesiology

Chloë Kerstein, B.S., SPT

Doctor of Physical Therapy

B.A. in Neuroscience

PPAR-α, PPAR-δ, PPAR-γ are ligand-activated transcription factors of the PPAR nuclear receptor superfamily that function to regulate metabolic homeostasis of the cell¹

• Subfamily of nuclear receptors
• PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes

Subtypes

There are three known subtypes:

1. PPAR-alpha
2. PPAR-delta
3. PPAR-gamma

PPAR-γ

PPAR-γ has 3 primary functions

1. Regulate anabolism of the adipose tissue¹
2. Important role in glucose metabolism¹
3. Important role in cardiac development¹

References

1.

Kökény G, Calvier L, Hansmann G. PPAR\(\gamma\) and TGF\(\beta\)-Major Regulators of Metabolism, Inflammation, and Fibrosis in the Lungs and Kidneys. International Journal of Molecular Sciences. 2021;22(19):10431. doi:10.3390/ijms221910431