C-Reactive Protein (CRP)

Authors
Affiliations

Doctor of Physical Therapy

B.S. in Kinesiology

Doctor of Physical Therapy

B.A. in Neuroscience

CRP was used as a measure of inflammation following ice baths, which we reviewed here in our journal club.

“C-reactive protein (CRP) is a test that measures the amount of a protein in the blood that signals acute inflammation. To determine a person’s risk for heart disease, a more sensitive CRP test, called high-sensitivity C-reactive protein (hs-CRP) assay, is available. A growing number of studies have determined that high levels of hs-CRP consistently predict recurrent coronary events in patients with unstable angina (USA) and acute MI. In addition, elevated hs-CRP levels are associated with lower survival rates in these patients with cardiovascular disease (see Box 3.2).32–34”1

Serum CRP

Serum CRP can be used as a marker of acute inflammation

Interpertation of CRP Values
Value Risk
<1mg/L Low
1.0 - 3.0 mg/L Average
>3.0 mg/L High

Test validity: High sensitivity CRP (hs-CRP) = predictive of recurrent coronary events

Delayed onset muscle soreness

“Armstrong (2) proposed that DOMS is associated with damage to the sarcolemma, and ensuing inflammation. Inflammation denotes the onset of the healing process and may be indicated by a rise in Creactive protein (CRP)”2

References

1.
Paz JC, West MP, Panasci K, Greenwood KC, eds. Acute Care Handbook for Physical Therapists. 5th ed. Elsevier; 2020.
2.
Draper SN, Kullman EL, Sparks KE, Little K, Thoman J. Effects of Intermittent Pneumatic Compression on Delayed Onset Muscle Soreness (DOMS) in Long Distance Runners. International Journal of Exercise Science. 2020;13(2):75-86.

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