High-density lipoprotein (HDL)

Authors

Affiliations

Nate Yomogida, B.S., SPT

Doctor of Physical Therapy

B.S. in Kinesiology

Chloë Kerstein, B.S., SPT

Doctor of Physical Therapy

B.A. in Neuroscience

Serum

U-shaped Curve

When observing the relationship between HDL and mortality a U-shaped curve emerges.

Both abnormally low and abnormally high of HDL-C are associated with increased risk of all-cause mortality and atherosclerotic cardiovascular disease mortality¹.

REad:

• Liu C, Dhindsa D, Almuwaqqat Z, Sun YV, Quyyumi AA. Very high high-density lipoprotein cholesterol levels and cardiovascular mortality. Am J Cardiol. 2022;167(188):120–1.Among individuals without overt CVD, very-high HDL-C was independently associated with a higher risk of cardiovascular and all-cause mortality in men, but not women. 10••. Liu C, Dhindsa D, - Almuwaqqat Z, Ko YA, Mehta A, Alkhoder AA, et al. Association between high-density lipoprotein cholesterol levels and adverse cardiovascular outcomes in high-risk populations. JAMA Cardiol. 2022;7(7):672–80. [PubMed: 35583863] Among individuals with coronary artery disease, very-high HDL-C was independently associated with a higher risk of cardiovascular and all-cause mortality.

Abnormally low

Abnormally high

1.

Razavi AC, Mehta A, Jain V, et al. High-Density Lipoprotein Cholesterol in Atherosclerotic Cardiovascular Disease Risk Assessment: Exploring and Explaining the "U"-Shaped Curve. Current Cardiology Reports. 2023;25(12):1725-1733. doi:10.1007/s11886-023-01987-3